High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

INTRODUCTION: Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer’s disease (AD) and other tauopathies. In most AD subjects, wild-type (WT) tau aggregates and accumulates in neurofibrillary tangles and dystrophic neurites i...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Wheeler, Jeanna M., McMillan, Pamela J., Hawk, Michele, Iba, Michiyo, Robinson, Linda, Xu, George J., Dombroski, Beth A., Jeong, Doori, Dichter, Marc A., Juul, Halvor, Loomis, Elaine, Raskind, Murray, Leverenz, James B., Trojanowski, John Q., Lee, Virginia M.Y., Schellenberg, Gerard D., Kraemer, Brian C.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453289/
https://ncbi.nlm.nih.gov/pubmed/26041339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0210-6
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