High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

INTRODUCTION: Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer’s disease (AD) and other tauopathies. In most AD subjects, wild-type (WT) tau aggregates and accumulates in neurofibrillary tangles and dystrophic neurites i...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Wheeler, Jeanna M., McMillan, Pamela J., Hawk, Michele, Iba, Michiyo, Robinson, Linda, Xu, George J., Dombroski, Beth A., Jeong, Doori, Dichter, Marc A., Juul, Halvor, Loomis, Elaine, Raskind, Murray, Leverenz, James B., Trojanowski, John Q., Lee, Virginia M.Y., Schellenberg, Gerard D., Kraemer, Brian C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453289/
https://ncbi.nlm.nih.gov/pubmed/26041339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0210-6
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