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Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain
Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity in two mouse models of tauopathy. Transgenic PS19 m...
में बचाया:
| में प्रकाशित: | Sci Transl Med |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7311111/ https://ncbi.nlm.nih.gov/pubmed/31852801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao6545 |
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