Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity in two mouse models of tauopathy. Transgenic PS19 m...

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Pubblicato in:Sci Transl Med
Autori principali: Wheeler, Jeanna M., McMillan, Pamela, Strovas, Timothy J., Liachko, Nicole F., Amlie-Wolf, Alexandre, Kow, Rebecca L., Klein, Ronald L., Szot, Patricia, Robinson, Linda, Guthrie, Chris, Saxton, Aleen, Kanaan, Nicholas M., Raskind, Murray, Peskind, Elaine, Trojanowski, John Q., Lee, Virginia M. Y., Wang, Li-San, Keene, C. Dirk, Bird, Thomas, Schellenberg, Gerard D., Kraemer, Brian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311111/
https://ncbi.nlm.nih.gov/pubmed/31852801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao6545
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