Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity in two mouse models of tauopathy. Transgenic PS19 m...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wheeler, Jeanna M., McMillan, Pamela, Strovas, Timothy J., Liachko, Nicole F., Amlie-Wolf, Alexandre, Kow, Rebecca L., Klein, Ronald L., Szot, Patricia, Robinson, Linda, Guthrie, Chris, Saxton, Aleen, Kanaan, Nicholas M., Raskind, Murray, Peskind, Elaine, Trojanowski, John Q., Lee, Virginia M. Y., Wang, Li-San, Keene, C. Dirk, Bird, Thomas, Schellenberg, Gerard D., Kraemer, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311111/
https://ncbi.nlm.nih.gov/pubmed/31852801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao6545
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