Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity in two mouse models of tauopathy. Transgenic PS19 m...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Transl Med
मुख्य लेखकों: Wheeler, Jeanna M., McMillan, Pamela, Strovas, Timothy J., Liachko, Nicole F., Amlie-Wolf, Alexandre, Kow, Rebecca L., Klein, Ronald L., Szot, Patricia, Robinson, Linda, Guthrie, Chris, Saxton, Aleen, Kanaan, Nicholas M., Raskind, Murray, Peskind, Elaine, Trojanowski, John Q., Lee, Virginia M. Y., Wang, Li-San, Keene, C. Dirk, Bird, Thomas, Schellenberg, Gerard D., Kraemer, Brian
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311111/
https://ncbi.nlm.nih.gov/pubmed/31852801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao6545
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