Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity in two mouse models of tauopathy. Transgenic PS19 m...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Wheeler, Jeanna M., McMillan, Pamela, Strovas, Timothy J., Liachko, Nicole F., Amlie-Wolf, Alexandre, Kow, Rebecca L., Klein, Ronald L., Szot, Patricia, Robinson, Linda, Guthrie, Chris, Saxton, Aleen, Kanaan, Nicholas M., Raskind, Murray, Peskind, Elaine, Trojanowski, John Q., Lee, Virginia M. Y., Wang, Li-San, Keene, C. Dirk, Bird, Thomas, Schellenberg, Gerard D., Kraemer, Brian
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311111/
https://ncbi.nlm.nih.gov/pubmed/31852801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao6545
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