Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

Members of the 70-kDa heat shock family can control and manipulate a host of oncogenic client proteins. This role of Hsp70 in both the folding and degradation of these client proteins makes it a potential drug target for certain forms of cancer. The phenothiazine family of compounds, as well as the...

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Bibliografske podrobnosti
Main Authors: Koren, John, Jinwal, Umesh K., Jin, Ying, O'Leary, John, Jones, Jeff R., Johnson, Amelia G., Blair, Laura J., Abisambra, Jose F., Chang, Lyra, Miyata, Yoshinari, Cheng, Anna M., Guo, Jianping, Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807306/
https://ncbi.nlm.nih.gov/pubmed/19889640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057208
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