Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

Members of the 70-kDa heat shock family can control and manipulate a host of oncogenic client proteins. This role of Hsp70 in both the folding and degradation of these client proteins makes it a potential drug target for certain forms of cancer. The phenothiazine family of compounds, as well as the...

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Autori principali: Koren, John, Jinwal, Umesh K., Jin, Ying, O'Leary, John, Jones, Jeff R., Johnson, Amelia G., Blair, Laura J., Abisambra, Jose F., Chang, Lyra, Miyata, Yoshinari, Cheng, Anna M., Guo, Jianping, Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807306/
https://ncbi.nlm.nih.gov/pubmed/19889640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057208
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