Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

Clearance of misfolded proteins in the endoplasmic reticulum (ER) is traditionally handled by ER-associated degradation (ERAD), a process that requires retro-translocation and ubiquitination mediated by a luminal chaperone network. Here we investigated whether the secreted, glaucoma-associated prote...

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Detalhes bibliográficos
Main Authors: Suntharalingam, Amirthaa, Abisambra, Jose F., O'Leary, John C., Koren, John, Zhang, Bo, Joe, Myung Kuk, Blair, Laura J., Hill, Shannon E., Jinwal, Umesh K., Cockman, Matthew, Duerfeldt, Adam S., Tomarev, Stanislav, Blagg, Brian S. J., Lieberman, Raquel L., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504779/
https://ncbi.nlm.nih.gov/pubmed/23035116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384800
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