Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

BACKGROUND: It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment. However, recent evidence suggests that tau tangles are not the entity responsible for...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: O'Leary, John C, Li, Qingyou, Marinec, Paul, Blair, Laura J, Congdon, Erin E, Johnson, Amelia G, Jinwal, Umesh K, Koren, John, Jones, Jeffrey R, Kraft, Clara, Peters, Melinda, Abisambra, Jose F, Duff, Karen E, Weeber, Edwin J, Gestwicki, Jason E, Dickey, Chad A
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2010
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989315/
https://ncbi.nlm.nih.gov/pubmed/21040568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-45
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