The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and...

Por Radominska-Pandya, Anna, Bratton, Stacie M., Redinbo, Matthew R., Miley, Michael J.
Publicado em 2010

Computational design of a symmetric homodimer using β-strand assembly

Por Stranges, P. Benjamin, Machius, Mischa, Miley, Michael J., Tripathy, Ashutosh, Kuhlman, Brian
Publicado em 2011

Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer

Por Der, Bryan S., Machius, Mischa, Miley, Michael J., Mills, Jeffrey L., Szyperski, Thomas, Kuhlman, Brian
Publicado em 2011

Increasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic Core

Por Murphy, Grant S., Mills, Jeffrey L., Miley, Michael J., Machius, Mischa, Szyperski, Thomas, Kuhlman, Brian
Publicado em 2012

Functional Characterization of the Multidomain F Plasmid TraI Relaxase-Helicase

Por Cheng, Yuan, McNamara, Dan E., Miley, Michael J., Nash, Rebekah P., Redinbo, Matthew R.
Publicado em 2011

Dissecting the human serum antibody response to secondary dengue virus infections

Por Patel, Bhumi, Longo, Patti, Miley, Michael J., Montoya, Magelda, Harris, Eva, de Silva, Aravinda M.
Publicado no PLoS Negl Trop Dis (2017)

Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution

Por Miley, Michael J., Messaoudi, Ilhem, Metzner, Beatrix M., Wu, Yudong, Nikolich-Žugich, Janko, Fremont, Daved H.
Publicado em 2004

Crystal Structure of the Cofactor-Binding Domain of the Human Phase II Drug-Metabolism Enzyme UDP-Glucuronosyltransferase 2B7

Por Miley, Michael J., Zielinska, Agnieszka K., Keenan, Jeffrey E., Bratton, Stacie M., Radominska-Pandya, Anna, Redinbo, Matthew R.
Publicado em 2007

In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers

Por Metz, Stefan W., Gallichotte, Emily N., Brackbill, Alex, Premkumar, Lakshmanane, Miley, Michael J., Baric, Ralph, de Silva, Aravinda M.
Publicado no Sci Rep (2017)

Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme

Por Danshina, Polina V., Qu, Weidong, Temple, Brenda R., Rojas, Rafael J., Miley, Michael J., Machius, Mischa, Betts, Laurie, O'Brien, Deborah A.
Publicado no Mol Hum Reprod (2016)

Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein α Subunit Mutants

Por Bosch, Dustin E., Kimple, Adam J., Sammond, Deanne W., Muller, Robin E., Miley, Michael J., Machius, Mischa, Kuhlman, Brian, Willard, Francis S., Siderovski, David P.
Publicado em 2011

Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses

Por Metz, Stefan W., Tian, Shaomin, Hoekstra, Gabriel, Yi, Xianwen, Stone, Michelle, Horvath, Katie, Miley, Michael J., DeSimone, Joseph, Luft, Chris J., de Silva, Aravinda M.
Publicado no PLoS Negl Trop Dis (2016)

The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis

Por Xiong, Yan, Patana, Anne-Sisko, Miley, Michael J., Zielinska, Agnieszka K., Bratton, Stacie M., Miller, Grover P., Goldman, Adrian, Finel, Moshe, Redinbo, Matt R., Radominska-Pandya, Anna
Publicado em 2007

Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

Por Wang, Xiaodong, Liu, Jing, Zhang, Weihe, Stashko, Michael A., Nichols, James, Miley, Michael J., Norris-Drouin, Jacqueline, Chen, Zhilong, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H. Shelton, Kireev, Dmitri, Frye, Stephen V.
Publicado no ACS Med Chem Lett (2016)

Discovery of Macrocyclic Pyrimidines as MerTK-specific Inhibitors

Por McIver, Andrew L., Zhang, Weihe, Liu, Qingyang, Jiang, Xinpeng, Stashko, Michael A., Nichols, James, Miley, Michael J, Norris-Drouin, Jacqueline, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H Shelton, Kireev, Dmitri, Frye, Stephen V., Wang, Xiaodong
Publicado no ChemMedChem (2017)

Mutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma

Por Burd, Christin E., Liu, Wenjin, Huynh, Minh V., Waqas, Meriam A., Gillahan, James E., Clark, Kelly S., Fu, Kailing, Martin, Brit L., Jeck, William R., Souroullas, George P., Darr, David B., Zedek, Daniel C., Miley, Michael J., Baguley, Bruce C., Campbell, Sharon L., Sharpless, Norman E.
Publicado no Cancer Discov (2014)

Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

Por Liu, Jing, Yang, Chao, Simpson, Catherine, DeRyckere, Deborah, Van Deusen, Amy, Miley, Michael J., Kireev, Dmitri, Norris-Drouin, Jacqueline, Sather, Susan, Hunter, Debra, Korboukh, Victoria K., Patel, Hari S., Janzen, William P., Machius, Mischa, Johnson, Gary L., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2012

Pseudo Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Por Zhang, Weihe, Zhang, Dehui, Stashko, Michael A, DeRyckere, Deborah, Hunter, Debra, Kireev, Dmitri, Miley, Michael J, Cummings, Christopher, Lee, Minjung, Norris-Drouin, Jacqueline, Stewart, Wendy M., Sather, Susan, Zhou, Yingqiu, Kirkpatrick, Gregory, Machius, Mischa, Janzen, William P., Earp, H Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2013

Correction to Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

Por Liu, Jing, Yang, Chao, Simpson, Catherine, DeRyckere, Deborah, Deusen, Amy Van, Miley, Michael J., Kireev, Dmitri, Norris-Drouin, Jacqueline, Sather, Susan, Hunter, Debra, Korboukh, Victoria K., Patel, Hari S., Janzen, William P., Machius, Mischa, Johnson, Gary L., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2014

Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

Por Zhang, Weihe, McIver, Andrew L., Stashko, Michael A., DeRyckere, Deborah, Branchford, Brian R., Hunter, Debra, Kireev, Dmitri, Miley, Michael J., Norris-Drouin, Jacqueline, Stewart, Wendy M., Lee, Minjung, Sather, Susan, Zhou, Yingqiu, Di Paola, Jorge A., Machius, Mischa, Janzen, William P., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2013