In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers

Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes. The mature flavivirus infectious virion has 90 envelope (E) protein homo-dimers that pack tightly to form a smooth protein coat with icosahedr...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Metz, Stefan W., Gallichotte, Emily N., Brackbill, Alex, Premkumar, Lakshmanane, Miley, Michael J., Baric, Ralph, de Silva, Aravinda M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495877/
https://ncbi.nlm.nih.gov/pubmed/28674411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04767-6
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