Increasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic Core

Protein design tests our understanding of protein stability and structure. Successful design methods should allow the exploration of sequence space not found in nature. However, when redesigning naturally occurring protein structures most fixed backbone design algorithms return amino acid sequences...

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Bibliographic Details
Main Authors: Murphy, Grant S., Mills, Jeffrey L., Miley, Michael J., Machius, Mischa, Szyperski, Thomas, Kuhlman, Brian
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372604/
https://ncbi.nlm.nih.gov/pubmed/22632833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.03.026
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