Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme

STUDY HYPOTHESIS: Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive developm...

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Publicado en:Mol Hum Reprod
Autores principales: Danshina, Polina V., Qu, Weidong, Temple, Brenda R., Rojas, Rafael J., Miley, Michael J., Machius, Mischa, Betts, Laurie, O'Brien, Deborah A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884916/
https://ncbi.nlm.nih.gov/pubmed/26921398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaw016
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