Pseudo Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer therapeutic target. A structure-based drug design approach using a pseudo-ring replacement strategy...

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Hoofdauteurs: Zhang, Weihe, Zhang, Dehui, Stashko, Michael A, DeRyckere, Deborah, Hunter, Debra, Kireev, Dmitri, Miley, Michael J, Cummings, Christopher, Lee, Minjung, Norris-Drouin, Jacqueline, Stewart, Wendy M., Sather, Susan, Zhou, Yingqiu, Kirkpatrick, Gregory, Machius, Mischa, Janzen, William P., Earp, H Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980660/
https://ncbi.nlm.nih.gov/pubmed/24195762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401387j
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