ETV6 mutations define a new cancer predisposition syndrome

Por Kirkpatrick, Gregory, Noetzli, Leila, Di Paola, Jorge, Porter, Christopher C.
Publicado no Oncotarget (2015)

Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer

Por Cummings, Christopher T., Linger, Rachel M.A., Cohen, Rebecca A., Sather, Susan, Kirkpatrick, Gregory D., Davies, Kurtis D., DeRyckere, Deborah, Earp, H. Shelton, Graham, Douglas K.
Publicado no Oncotarget (2014)

Small molecule inhibition of MERTK is efficacious in non-small cell lung cancer models independent of driver oncogene status

Por Cummings, Christopher T., Zhang, Weihe, Davies, Kurtis D., Kirkpatrick, Gregory D., Zhang, Dehui, DeRyckere, Deborah, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Graham, Douglas K.
Publicado no Mol Cancer Ther (2015)

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

Por Lee-Sherick, Alisa B., Zhang, Weihe, Menachof, Kelly K., Hill, Amanda A., Rinella, Sean, Kirkpatrick, Gregory, Page, Lauren S., Stashko, Michael A., Jordan, Craig T., Wei, Qi, Liu, Jing, Zhang, Dehui, DeRyckere, Deborah, Wang, Xiaodong, Frye, Stephen, Earp, H. Shelton, Graham, Douglas K.
Publicado no Oncotarget (2015)

UNC2025, a MERTK small molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models

Por DeRyckere, Deborah, Lee-Sherick, Alisa B., Huey, Madeline G., Hill, Amanda A., Tyner, Jeffrey W., Jacobsen, Kristen M., Page, Lauren S., Kirkpatrick, Gregory G., Eryildiz, Fatma, Montgomery, Stephanie A., Zhang, Weihe, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Graham, Douglas K.
Publicado no Clin Cancer Res (2016)

The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia

Por Minson, Katherine A., Smith, Catherine C., DeRyckere, Deborah, Libbrecht, Clara, Lee-Sherick, Alisa B., Huey, Madeline G., Lasater, Elisabeth A., Kirkpatrick, Gregory D., Stashko, Michael A., Zhang, Weihe, Jordan, Craig T., Kireev, Dmitri, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Shah, Neil P., Graham, Douglas K.
Publicado no JCI Insight (2016)

Pseudo Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Por Zhang, Weihe, Zhang, Dehui, Stashko, Michael A, DeRyckere, Deborah, Hunter, Debra, Kireev, Dmitri, Miley, Michael J, Cummings, Christopher, Lee, Minjung, Norris-Drouin, Jacqueline, Stewart, Wendy M., Sather, Susan, Zhou, Yingqiu, Kirkpatrick, Gregory, Machius, Mischa, Janzen, William P., Earp, H Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2013