Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

Mer and Flt3 receptor tyrosine kinases have been implicated as therapeutic targets in acute myeloid leukemia (AML). In this manuscript we describe UNC1666, a novel ATP-competitive small molecule tyrosine kinase inhibitor, which potently diminishes Mer and Flt3 phosphorylation in AML. Treatment with...

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Publicado en:Oncotarget
Autores principales: Lee-Sherick, Alisa B., Zhang, Weihe, Menachof, Kelly K., Hill, Amanda A., Rinella, Sean, Kirkpatrick, Gregory, Page, Lauren S., Stashko, Michael A., Jordan, Craig T., Wei, Qi, Liu, Jing, Zhang, Dehui, DeRyckere, Deborah, Wang, Xiaodong, Frye, Stephen, Earp, H. Shelton, Graham, Douglas K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466645/
https://ncbi.nlm.nih.gov/pubmed/25762638
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