Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

[Image: see text] Ectopic Mer expression promotes pro-survival signaling and contributes to leukemogenesis and chemoresistance in childhood acute lymphoblastic leukemia (ALL). Consequently, Mer kinase inhibitors may promote leukemic cell death and further act as chemosensitizers increasing efficacy...

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Detalhes bibliográficos
Main Authors: Liu, Jing, Yang, Chao, Simpson, Catherine, DeRyckere, Deborah, Van Deusen, Amy, Miley, Michael J., Kireev, Dmitri, Norris-Drouin, Jacqueline, Sather, Susan, Hunter, Debra, Korboukh, Victoria K., Patel, Hari S., Janzen, William P., Machius, Mischa, Johnson, Gary L., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365829/
https://ncbi.nlm.nih.gov/pubmed/22662287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200239k
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