Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

[Image: see text] Ectopic Mer expression promotes pro-survival signaling and contributes to leukemogenesis and chemoresistance in childhood acute lymphoblastic leukemia (ALL). Consequently, Mer kinase inhibitors may promote leukemic cell death and further act as chemosensitizers increasing efficacy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Jing, Yang, Chao, Simpson, Catherine, DeRyckere, Deborah, Van Deusen, Amy, Miley, Michael J., Kireev, Dmitri, Norris-Drouin, Jacqueline, Sather, Susan, Hunter, Debra, Korboukh, Victoria K., Patel, Hari S., Janzen, William P., Machius, Mischa, Johnson, Gary L., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2012
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365829/
https://ncbi.nlm.nih.gov/pubmed/22662287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200239k
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