Mutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma

N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an N-Ras(Q61R) knock-in allele to similarly designed K-Ras(G12D) and N-Ras(G12D) alleles. With concomitant p16...

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Publicado en:Cancer Discov
Autores principales: Burd, Christin E., Liu, Wenjin, Huynh, Minh V., Waqas, Meriam A., Gillahan, James E., Clark, Kelly S., Fu, Kailing, Martin, Brit L., Jeck, William R., Souroullas, George P., Darr, David B., Zedek, Daniel C., Miley, Michael J., Baguley, Bruce C., Campbell, Sharon L., Sharpless, Norman E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258185/
https://ncbi.nlm.nih.gov/pubmed/25252692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0729
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