Mutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma

N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an N-Ras(Q61R) knock-in allele to similarly designed K-Ras(G12D) and N-Ras(G12D) alleles. With concomitant p16...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Burd, Christin E., Liu, Wenjin, Huynh, Minh V., Waqas, Meriam A., Gillahan, James E., Clark, Kelly S., Fu, Kailing, Martin, Brit L., Jeck, William R., Souroullas, George P., Darr, David B., Zedek, Daniel C., Miley, Michael J., Baguley, Bruce C., Campbell, Sharon L., Sharpless, Norman E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258185/
https://ncbi.nlm.nih.gov/pubmed/25252692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0729
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