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Mutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma
N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an N-Ras(Q61R) knock-in allele to similarly designed K-Ras(G12D) and N-Ras(G12D) alleles. With concomitant p16...
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| Publicado no: | Cancer Discov |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258185/ https://ncbi.nlm.nih.gov/pubmed/25252692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0729 |
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