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Mutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma

N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an N-Ras(Q61R) knock-in allele to similarly designed K-Ras(G12D) and N-Ras(G12D) alleles. With concomitant p16...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Burd, Christin E., Liu, Wenjin, Huynh, Minh V., Waqas, Meriam A., Gillahan, James E., Clark, Kelly S., Fu, Kailing, Martin, Brit L., Jeck, William R., Souroullas, George P., Darr, David B., Zedek, Daniel C., Miley, Michael J., Baguley, Bruce C., Campbell, Sharon L., Sharpless, Norman E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258185/
https://ncbi.nlm.nih.gov/pubmed/25252692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0729
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