Mutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma

N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an N-Ras(Q61R) knock-in allele to similarly designed K-Ras(G12D) and N-Ras(G12D) alleles. With concomitant p16...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Burd, Christin E., Liu, Wenjin, Huynh, Minh V., Waqas, Meriam A., Gillahan, James E., Clark, Kelly S., Fu, Kailing, Martin, Brit L., Jeck, William R., Souroullas, George P., Darr, David B., Zedek, Daniel C., Miley, Michael J., Baguley, Bruce C., Campbell, Sharon L., Sharpless, Norman E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258185/
https://ncbi.nlm.nih.gov/pubmed/25252692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0729
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker