Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein α Subunit Mutants

GoLoco motif proteins bind to the inhibitory G(i) subclass of G-protein α subunits and slow the release of bound GDP; this interaction is considered critical to asymmetric cell division and neuro-epithelium and epithelial progenitor differentiation. To provide protein tools for interrogating the pre...

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Detalhes bibliográficos
Main Authors: Bosch, Dustin E., Kimple, Adam J., Sammond, Deanne W., Muller, Robin E., Miley, Michael J., Machius, Mischa, Kuhlman, Brian, Willard, Francis S., Siderovski, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030341/
https://ncbi.nlm.nih.gov/pubmed/21115486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190496
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