A High-Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction

The GoLoco motif is a short Gα-binding polypeptide sequence. It is often found in proteins that regulate cell-surface receptor signaling, such as RGS12, as well as in proteins that regulate mitotic spindle orientation and force generation during cell division, such as GPSM2/LGN. Here, we describe a...

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Autores principales: Kimple, Adam J., Yasgar, Adam, Hughes, Mark, Jadhav, Ajit, Willard, Francis S., Muller, Robin E., Austin, Christopher P., Inglese, James, Ibeanu, Gordon C., Siderovski, David P., Simeonov, Anton
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440576/
https://ncbi.nlm.nih.gov/pubmed/18537560
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