A Point Mutation to Gα(i) Selectively Blocks GoLoco Motif Binding: DIRECT EVIDENCE FOR Gα·GoLoco COMPLEXES IN MITOTIC SPINDLE DYNAMICS

Heterotrimeric G-protein Gα subunits and GoLoco motif proteins are key members of a conserved set of regulatory proteins that influence invertebrate asymmetric cell division and vertebrate neuroepithelium and epithelial progenitor differentiation. GoLoco motif proteins bind selectively to the inhibi...

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Autors principals: Willard, Francis S., Zheng, Zhen, Guo, Juan, Digby, Gregory J., Kimple, Adam J., Conley, Jason M., Johnston, Christopher A., Bosch, Dustin, Willard, Melinda D., Watts, Val J., Lambert, Nevin A., Ikeda, Stephen R., Du, Quansheng, Siderovski, David P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605979/
https://ncbi.nlm.nih.gov/pubmed/18984596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804936200
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