Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution

Major histocompatibility complex (MHC) class I variants H-2K(b) and H-2K(bm8) differ primarily in the B pocket of the peptide-binding groove, which serves to sequester the P2 secondary anchor residue. This polymorphism determines resistance to lethal herpes simplex virus (HSV-1) infection by modulat...

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Main Authors: Miley, Michael J., Messaoudi, Ilhem, Metzner, Beatrix M., Wu, Yudong, Nikolich-Žugich, Janko, Fremont, Daved H.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211956/
https://ncbi.nlm.nih.gov/pubmed/15557346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040217
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