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Evolution of the antigen-specific CD8+ TCR repertoire across the lifespan: evidence for clonal homogenization of the old TCR repertoire ()
Defects in T-cell responses against pathogens and reduced diversity of T cell receptors (TCR) have been described at both extremes of the lifespan. Yet, we still lack information on how antigen-specific T cell populations are maintained and/or altered in neonates and the aged. Here, for the first ti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119821/ https://ncbi.nlm.nih.gov/pubmed/21248263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003013 |
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