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Evolution of the antigen-specific CD8+ TCR repertoire across the lifespan: evidence for clonal homogenization of the old TCR repertoire ()

Defects in T-cell responses against pathogens and reduced diversity of T cell receptors (TCR) have been described at both extremes of the lifespan. Yet, we still lack information on how antigen-specific T cell populations are maintained and/or altered in neonates and the aged. Here, for the first ti...

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書誌詳細
主要な著者: Rudd, Brian D., Venturi, Vanessa, Davenport, Miles P., Nikolich-Zugich, Janko
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119821/
https://ncbi.nlm.nih.gov/pubmed/21248263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003013
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