Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection

Lifelong interactions between host and the ubiquitous and persistent cytomegalovirus (CMV) have been proposed to contribute to the age-related decline in immunity. Prior work from us and others found some support for that idea, yet evidence that this led to increased vulnerability to other infection...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Smithey, Megan J., Venturi, Vanessa, Davenport, Miles P., Buntzman, Adam S., Vincent, Benjamin G., Frelinger, Jeffrey A., Nikolich-Žugich, Janko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055168/
https://ncbi.nlm.nih.gov/pubmed/29967140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719451115
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