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Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection

Lifelong interactions between host and the ubiquitous and persistent cytomegalovirus (CMV) have been proposed to contribute to the age-related decline in immunity. Prior work from us and others found some support for that idea, yet evidence that this led to increased vulnerability to other infection...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Smithey, Megan J., Venturi, Vanessa, Davenport, Miles P., Buntzman, Adam S., Vincent, Benjamin G., Frelinger, Jeffrey A., Nikolich-Žugich, Janko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055168/
https://ncbi.nlm.nih.gov/pubmed/29967140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719451115
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