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Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense
Peripheral T cell diversity is virtually constant in the young, but is invariably reduced in aged mice and humans. CD8(+) T cell clonal expansions (TCE) are the most drastic manifestation of, and possible contributors to, this reduced diversity. We show that the presence of TCE results in reduced CD...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211915/ https://ncbi.nlm.nih.gov/pubmed/15545358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040437 |
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