Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense

Peripheral T cell diversity is virtually constant in the young, but is invariably reduced in aged mice and humans. CD8(+) T cell clonal expansions (TCE) are the most drastic manifestation of, and possible contributors to, this reduced diversity. We show that the presence of TCE results in reduced CD...

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Hlavní autoři: Messaoudi, Ilhem, LeMaoult, Joël, Guevara-Patino, Jose A., Metzner, Beatrix M., Nikolich-Žugich, Janko
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211915/
https://ncbi.nlm.nih.gov/pubmed/15545358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040437
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