Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes

Por Hu, Jiazhi, Tepsuporn, Suprawee, Meyers, Robin M., Gostissa, Monica, Alt, Frederick W.
Publicado em 2014

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

Por Frock, Richard L., Hu, Jiazhi, Meyers, Robin M., Ho, Yu-Jui, Kii, Erina, Alt, Frederick W.
Publicado no Nat Biotechnol (2014)

Detecting DNA Double-Stranded Breaks in Mammalian Genomes by Linear Amplification-mediated High-Throughput Genome-wide Translocation Sequencing (LAM-HTGTS)

Por Hu, Jiazhi, Meyers, Robin M., Dong, Junchao, Panchakshari, Rohit A., Alt, Frederick W., Frock, Richard L.
Publicado no Nat Protoc (2016)

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

Por Wei, Pei-Chi, Chang, Amelia N., Kao, Jennifer, Du, Zhou, Meyers, Robin M., Alt, Frederick W., Schwer, Bjoern
Publicado no Cell (2016)

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

Por Schwer, Bjoern, Wei, Pei-Chi, Chang, Amelia N., Kao, Jennifer, Du, Zhou, Meyers, Robin M., Alt, Frederick W.
Publicado no Proc Natl Acad Sci U S A (2016)

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes

Por Hu, Jiazhi, Zhang, Yu, Zhao, Lijuan, Frock, Richard L., Du, Zhou, Meyers, Robin M., Meng, Fei-long, Schatz, David G., Alt, Frederick W.
Publicado no Cell (2015)

Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes

Por de Bruin, Lisa Ott, Yang, Wei, Capuder, Kelly, Lee, Yu Nee, Antolini, Maddalena, Meyers, Robin, Gellert, Martin, Musunuru, Kiran, Manis, John, Notarangelo, Luigi
Publicado no Oncotarget (2016)

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

Por Gostissa, Monica, Schwer, Bjoern, Chang, Amelia, Dong, Junchao, Meyers, Robin M., Marecki, Gregory T., Choi, Vivian W., Chiarle, Roberto, Zarrin, Ali A., Alt, Frederick W.
Publicado em 2014

Microbial colonization influences early B-lineage development in the gut lamina propria

Por Wesemann, Duane R., Portuguese, Andrew J., Meyers, Robin M., Gallagher, Michael P., Cluff-Jones, Kendra, Magee, Jennifer M., Panchakshari, Rohit A., Rodig, Scott J., Kepler, Thomas B., Alt, Frederick W.
Publicado em 2013

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

Por Yeap, Leng-Siew, Hwang, Joyce K., Du, Zhou, Meyers, Robin M., Meng, Fei-Long, Jakubauskaitė, Agnė, Liu, Mengyuan, Mani, Vinidhra, Neuberg, Donna, Kepler, Thomas B., Wang, Jing H., Alt, Frederick W.
Publicado no Cell (2015)

Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

Por Hwang, Joyce K., Wang, Chong, Du, Zhou, Meyers, Robin M., Kepler, Thomas B., Neuberg, Donna, Kwong, Peter D., Mascola, John R., Joyce, M. Gordon, Bonsignori, Mattia, Haynes, Barton F., Yeap, Leng-Siew, Alt, Frederick W.
Publicado no Proc Natl Acad Sci U S A (2017)

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

Por Dong, Junchao, Panchakshari, Rohit A., Zhang, Tingting, Zhang, Yu, Hu, Jiazhi, Volpi, Sabrina A., Meyers, Robin M., Ho, Yu-Jui, Du, Zhou, Robbiani, Davide F., Meng, Feilong, Gostissa, Monica, Nussenzweig, Michel C., Manis, John P., Alt, Frederick W.
Publicado no Nature (2015)

Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability

Por Meng, Fei-Long, Du, Zhou, Federation, Alexander, Hu, Jiazhi, Wang, Qiao, Kieffer-Kwon, Kyong-Rim, Meyers, Robin M., Amor, Corina, Wasserman, Caitlyn R., Neuberg, Donna, Casellas, Rafael, Nussenzweig, Michel C., Bradner, James E., Liu, X. Shirley, Alt, Frederick W.
Publicado no Cell (2014)

Defining a Cancer Dependency Map

Por Tsherniak, Aviad, Vazquez, Francisca, Montgomery, Phil G., Weir, Barbara A., Kryukov, Gregory, Cowley, Glenn S., Gill, Stanley, Harrington, William F., Pantel, Sasha, Krill-Burger, John M., Meyers, Robin M., Ali, Levi, Goodale, Amy, Lee, Yenarae, Jiang, Guozhi, Hsiao, Jessica, Gerath, William F.J., Howell, Sara, Merkel, Erin, Ghandi, Mahmoud, Garraway, Levi A., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C.
Publicado no Cell (2017)

Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting

Por Aguirre, Andrew J., Meyers, Robin M., Weir, Barbara A., Vazquez, Francisca, Zhang, Cheng-Zhong, Ben-David, Uri, Cook, April, Ha, Gavin, Harrington, William F., Doshi, Mihir B., Kost-Alimova, Maria, Gill, Stanley, Xu, Han, Ali, Levi D., Jiang, Guozhi, Pantel, Sasha, Lee, Yenarae, Goodale, Amy, Cherniack, Andrew D., Oh, Coyin, Kryukov, Gregory, Cowley, Glenn S., Garraway, Levi A., Stegmaier, Kimberly, Roberts, Charles W., Golub, Todd R., Meyerson, Matthew, Root, David E., Tsherniak, Aviad, Hahn, William C.
Publicado no Cancer Discov (2016)

Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

Por Meyers, Robin M., Bryan, Jordan G., McFarland, James M., Weir, Barbara A., Sizemore, Ann E., Xu, Han, Dharia, Neekesh V., Montgomery, Phillip G., Cowley, Glenn S., Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D., Jiang, Guozhi, Lubonja, Rakela, Harrington, William F., Strickland, Matthew, Wu, Ting, Hawes, Derek C., Zhivich, Victor A., Wyatt, Meghan R., Kalani, Zohra, Chang, Jaime J., Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R., Boehm, Jesse S., Vazquez, Francisca, Root, David E., Hahn, William C., Tsherniak, Aviad
Publicado no Nat Genet (2017)

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

Por Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V., Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W. Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A., Cowley, Glenn S., Ali, Levi D., Pantel, Sasha, Jiang, Guozhi, Harrington, William F., Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M., Meyers, Robin M., Tsherniak, Aviad, Root, David E., Bradner, James E., Golub, Todd R., Roberts, Charles W.M., Hahn, William C., Weiss, William A., Thiele, Carol J., Stegmaier, Kimberly
Publicado no J Clin Invest (2017)

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

Por Ng, Samuel Y., Yoshida, Noriaki, Christie, Amanda L., Ghandi, Mahmoud, Dharia, Neekesh V., Dempster, Joshua, Murakami, Mark, Shigemori, Kay, Morrow, Sara N., Van Scoyk, Alexandria, Cordero, Nicolas A., Stevenson, Kristen E., Puligandla, Maneka, Haas, Brian, Lo, Christopher, Meyers, Robin, Gao, Galen, Cherniack, Andrew, Louissaint, Abner, Nardi, Valentina, Thorner, Aaron R., Long, Henry, Qiu, Xintao, Morgan, Elizabeth A., Dorfman, David M., Fiore, Danilo, Jang, Julie, Epstein, Alan L., Dogan, Ahmet, Zhang, Yanming, Horwitz, Steven M., Jacobsen, Eric D., Santiago, Solimar, Ren, Jian-Guo, Guerlavais, Vincent, Annis, D. Allen, Aivado, Manuel, Saleh, Mansoor N., Mehta, Amitkumar, Tsherniak, Aviad, Root, David, Vazquez, Francisca, Hahn, William C., Inghirami, Giorgio, Aster, Jon C., Weinstock, David M., Koch, Raphael
Publicado no Nat Commun (2018)