Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally from V, D, J gene segments. Each variable region contains three antigen-contacting complementarity-determining regio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hwang, Joyce K., Wang, Chong, Du, Zhou, Meyers, Robin M., Kepler, Thomas B., Neuberg, Donna, Kwong, Peter D., Mascola, John R., Joyce, M. Gordon, Bonsignori, Mattia, Haynes, Barton F., Yeap, Leng-Siew, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559054/
https://ncbi.nlm.nih.gov/pubmed/28747530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1709203114
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