Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologi...

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Autores principales: Li, Yuxing, O'Dell, Sijy, Walker, Laura M., Wu, Xueling, Guenaga, Javier, Feng, Yu, Schmidt, Stephen D., McKee, Krisha, Louder, Mark K., Ledgerwood, Julie E., Graham, Barney S., Haynes, Barton F., Burton, Dennis R., Wyatt, Richard T., Mascola, John R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165784/
https://ncbi.nlm.nih.gov/pubmed/21715490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00754-11
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