HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

Broadly neutralizing antibodies (bNAbs) have been isolated from selected HIV-1-infected individuals and shown to bind to conserved sites on the envelope glycoprotein (Env). However, circulating plasma virus in these donors is usually resistant to autologous isolated bNAbs, indicating that during chr...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lynch, Rebecca M., Wong, Patrick, Tran, Lillian, O'Dell, Sijy, Nason, Martha C., Li, Yuxing, Wu, Xueling, Mascola, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442379/
https://ncbi.nlm.nih.gov/pubmed/25631091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03608-14
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