HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: LaBranche, Celia C., McGuire, Andrew T., Gray, Matthew D., Behrens, Shay, Zhou, Tongqing, Sattentau, Quentin J., Peacock, James, Eaton, Amanda, Greene, Kelli, Gao, Hongmei, Tang, Haili, Perez, Lautaro G., Saunders, Kevin O., Mascola, John R., Haynes, Barton F., Stamatatos, Leonidas, Montefiori, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237427/
https://ncbi.nlm.nih.gov/pubmed/30395637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007431
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