HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency...

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Udgivet i:PLoS Pathog
Main Authors: LaBranche, Celia C., McGuire, Andrew T., Gray, Matthew D., Behrens, Shay, Zhou, Tongqing, Sattentau, Quentin J., Peacock, James, Eaton, Amanda, Greene, Kelli, Gao, Hongmei, Tang, Haili, Perez, Lautaro G., Saunders, Kevin O., Mascola, John R., Haynes, Barton F., Stamatatos, Leonidas, Montefiori, David C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237427/
https://ncbi.nlm.nih.gov/pubmed/30395637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007431
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