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Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells
High-throughput, genome-wide translocation sequencing (HTGTS) studies of activated B cells have revealed that DNA double-strand breaks (DSBs) capable of translocating to defined bait DSBs are enriched around the transcription start sites (TSSs) of active genes. We used the HTGTS approach to investig...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776469/ https://ncbi.nlm.nih.gov/pubmed/26873106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525564113 |
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