Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

High-throughput, genome-wide translocation sequencing (HTGTS) studies of activated B cells have revealed that DNA double-strand breaks (DSBs) capable of translocating to defined bait DSBs are enriched around the transcription start sites (TSSs) of active genes. We used the HTGTS approach to investig...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Schwer, Bjoern, Wei, Pei-Chi, Chang, Amelia N., Kao, Jennifer, Du, Zhou, Meyers, Robin M., Alt, Frederick W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776469/
https://ncbi.nlm.nih.gov/pubmed/26873106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525564113
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