Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay

We recently discovered 27 recurrent DNA double-strand break (DSB) clusters (RDCs) in mouse neural stem/progenitor cells (NSPCs). Most RDCs occurred across long, late-replicating RDC genes and were found only after mild inhibition of DNA replication. RDC genes share intriguing characteristics, includ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wei, Pei-Chi, Lee, Cheng-Sheng, Du, Zhou, Schwer, Bjoern, Zhang, Yuxiang, Kao, Jennifer, Zurita, Jeffrey, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828622/
https://ncbi.nlm.nih.gov/pubmed/29432181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719907115
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