Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay

We recently discovered 27 recurrent DNA double-strand break (DSB) clusters (RDCs) in mouse neural stem/progenitor cells (NSPCs). Most RDCs occurred across long, late-replicating RDC genes and were found only after mild inhibition of DNA replication. RDC genes share intriguing characteristics, includ...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Wei, Pei-Chi, Lee, Cheng-Sheng, Du, Zhou, Schwer, Bjoern, Zhang, Yuxiang, Kao, Jennifer, Zurita, Jeffrey, Alt, Frederick W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828622/
https://ncbi.nlm.nih.gov/pubmed/29432181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719907115
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