DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions

Ig heavy chain (IgH) class switch recombination (CSR) in B lymphocytes switches IgH constant regions to change antibody functions. CSR is initiated by DNA double-strand breaks (DSBs) within a donor IgH switch (S) region and a downstream acceptor S region. CSR is completed by fusing donor and accepto...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Panchakshari, Rohit A., Zhang, Xuefei, Kumar, Vipul, Du, Zhou, Wei, Pei-Chi, Kao, Jennifer, Dong, Junchao, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789958/
https://ncbi.nlm.nih.gov/pubmed/29311308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719988115
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