Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

Class switch recombination (CSR) in B lymphocytes is initiated by introduction of multiple DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons. CSR is completed by joining a DSB in the donor Sμ to a DSB in a downstream acceptor S...

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Hauptverfasser: Boboila, Cristian, Jankovic, Mila, Yan, Catherine T., Wang, Jing H., Wesemann, Duane R., Zhang, Tingting, Fazeli, Alex, Feldman, Lauren, Nussenzweig, Andre, Nussenzweig, Michel, Alt, Frederick W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840344/
https://ncbi.nlm.nih.gov/pubmed/20133803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915067107
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