Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

Class switch recombination (CSR) in B lymphocytes is initiated by introduction of multiple DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons. CSR is completed by joining a DSB in the donor Sμ to a DSB in a downstream acceptor S...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Boboila, Cristian, Jankovic, Mila, Yan, Catherine T., Wang, Jing H., Wesemann, Duane R., Zhang, Tingting, Fazeli, Alex, Feldman, Lauren, Nussenzweig, Andre, Nussenzweig, Michel, Alt, Frederick W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840344/
https://ncbi.nlm.nih.gov/pubmed/20133803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915067107
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky