Ku70 suppresses alternative end joining in G1-arrested progenitor B cells

Classical nonhomologous end joining (C-NHEJ) repairs DNA double-strand breaks (DSBs) throughout interphase but predominates in G1 phase when homologous recombination is unavailable. Complexes containing the Ku70/80 (“Ku”) and XRCC4/ligase IV (Lig4) core C-NHEJ factors are required, respectively, for...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Liang, Zhuoyi, Kumar, Vipul, Le Bouteiller, Marie, Zurita, Jeffrey, Kenrick, Josefin, Lin, Sherry G., Lou, Jiangman, Hu, Jianqiao, Ye, Adam Yongxin, Boboila, Cristian, Alt, Frederick W., Frock, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166026/
https://ncbi.nlm.nih.gov/pubmed/34006647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2103630118
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