IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

Antibody class switch recombination (CSR) in B lymphocytes joins two DNA double-strand breaks (DSBs) lying 100–200 kb apart within switch (S) regions in the immunoglobulin heavy-chain locus (IgH). CSR-activated B lymphocytes generate multiple S-region DSBs in the donor Sμ and in a downstream accepto...

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Main Authors: Gostissa, Monica, Schwer, Bjoern, Chang, Amelia, Dong, Junchao, Meyers, Robin M., Marecki, Gregory T., Choi, Vivian W., Chiarle, Roberto, Zarrin, Ali A., Alt, Frederick W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932927/
https://ncbi.nlm.nih.gov/pubmed/24550291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324176111
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