Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons(1,2). In mice, six additional sets...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Dong, Junchao, Panchakshari, Rohit A., Zhang, Tingting, Zhang, Yu, Hu, Jiazhi, Volpi, Sabrina A., Meyers, Robin M., Ho, Yu-Jui, Du, Zhou, Robbiani, Davide F., Meng, Feilong, Gostissa, Monica, Nussenzweig, Michel C., Manis, John P., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592165/
https://ncbi.nlm.nih.gov/pubmed/26308889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14970
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