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53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
Class switch recombination (CSR) diversifies antibodies by joining highly repetitive DNA elements, which are separated by 60–200 kbp. CSR is initiated by activation-induced cytidine deaminase, an enzyme that produces multiple DNA double-strand breaks (DSBs) in switch regions. Switch regions are join...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856023/ https://ncbi.nlm.nih.gov/pubmed/20368578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100244 |
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