53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

Class switch recombination (CSR) diversifies antibodies by joining highly repetitive DNA elements, which are separated by 60–200 kbp. CSR is initiated by activation-induced cytidine deaminase, an enzyme that produces multiple DNA double-strand breaks (DSBs) in switch regions. Switch regions are join...

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Detaylı Bibliyografya
Asıl Yazarlar: Bothmer, Anne, Robbiani, Davide F., Feldhahn, Niklas, Gazumyan, Anna, Nussenzweig, Andre, Nussenzweig, Michel C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856023/
https://ncbi.nlm.nih.gov/pubmed/20368578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100244
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