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53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks

When DNA double-strand breaks occur, the cell cycle stage has a major influence on the choice of the repair pathway employed. Specifically, nonhomologous end joining is the predominant mechanism used in the G(1) phase of the cell cycle, while homologous recombination becomes fully activated in S pha...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Daley, James M., Sung, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993578/
https://ncbi.nlm.nih.gov/pubmed/24469398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01639-13
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