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53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks

When DNA double-strand breaks occur, the cell cycle stage has a major influence on the choice of the repair pathway employed. Specifically, nonhomologous end joining is the predominant mechanism used in the G(1) phase of the cell cycle, while homologous recombination becomes fully activated in S pha...

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Detalhes bibliográficos
Main Authors: Daley, James M., Sung, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993578/
https://ncbi.nlm.nih.gov/pubmed/24469398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01639-13
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