53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

Class switch recombination (CSR) diversifies antibodies by joining highly repetitive DNA elements, which are separated by 60–200 kbp. CSR is initiated by activation-induced cytidine deaminase, an enzyme that produces multiple DNA double-strand breaks (DSBs) in switch regions. Switch regions are join...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bothmer, Anne, Robbiani, Davide F., Feldhahn, Niklas, Gazumyan, Anna, Nussenzweig, Andre, Nussenzweig, Michel C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856023/
https://ncbi.nlm.nih.gov/pubmed/20368578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100244
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