53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here we show that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the non-ho...

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Autors principals: Bunting, Samuel F., Callén, Elsa, Wong, Nancy, Chen, Hua-Tang, Polato, Federica, Gunn, Amanda, Bothmer, Anne, Feldhahn, Niklas, Fernandez-Capetillo, Oscar, Cao, Liu, Xu, Xiaoling, Deng, Chu-Xia, Finkel, Toren, Nussenzweig, Michel, Stark, Jeremy M., Nussenzweig, André
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857570/
https://ncbi.nlm.nih.gov/pubmed/20362325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.03.012
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