BRCA1 functions independently of homologous recombination in DNA interstrand cross-link repair

Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage response factor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyAD...

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Detalhes bibliográficos
Main Authors: Bunting, Samuel F, Callen, Elsa, Kozak, Marina L, Kim, Jung-Min, Wong, Nancy, Lopez-Contreras, Andres J, Ludwig, Thomas, Baer, Richard, Faryabi, Robert B, Malhowski, Amy, Chen, Hua-Tang, Fernandez-Capetillo, Oscar, D’Andrea, Alan, Nussenzweig, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340543/
https://ncbi.nlm.nih.gov/pubmed/22445484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.015
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