BRCA1 functions independently of homologous recombination in DNA interstrand cross-link repair

Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage response factor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyAD...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Bunting, Samuel F, Callen, Elsa, Kozak, Marina L, Kim, Jung-Min, Wong, Nancy, Lopez-Contreras, Andres J, Ludwig, Thomas, Baer, Richard, Faryabi, Robert B, Malhowski, Amy, Chen, Hua-Tang, Fernandez-Capetillo, Oscar, D’Andrea, Alan, Nussenzweig, Andre
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340543/
https://ncbi.nlm.nih.gov/pubmed/22445484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.015
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky