BRCA1 functions independently of homologous recombination in DNA interstrand cross-link repair

Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage response factor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyAD...

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Huvudupphovsmän: Bunting, Samuel F, Callen, Elsa, Kozak, Marina L, Kim, Jung-Min, Wong, Nancy, Lopez-Contreras, Andres J, Ludwig, Thomas, Baer, Richard, Faryabi, Robert B, Malhowski, Amy, Chen, Hua-Tang, Fernandez-Capetillo, Oscar, D’Andrea, Alan, Nussenzweig, Andre
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340543/
https://ncbi.nlm.nih.gov/pubmed/22445484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.015
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