BRCA1 functions independently of homologous recombination in DNA interstrand cross-link repair

Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage response factor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyAD...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Bunting, Samuel F, Callen, Elsa, Kozak, Marina L, Kim, Jung-Min, Wong, Nancy, Lopez-Contreras, Andres J, Ludwig, Thomas, Baer, Richard, Faryabi, Robert B, Malhowski, Amy, Chen, Hua-Tang, Fernandez-Capetillo, Oscar, D’Andrea, Alan, Nussenzweig, Andre
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340543/
https://ncbi.nlm.nih.gov/pubmed/22445484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.015
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller