A dominant mutation in human RAD51 reveals its function in DNA interstrand crosslink repair independent of homologous recombination

Repair of DNA interstrand crosslinks requires action of multiple DNA repair pathways, including homologous recombination. Here, we report a de novo heterozygous T131P mutation in RAD51/FANCR, the key recombinase essential for homologous recombination, in a patient with Fanconi anemia-like phenotype....

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wang, Anderson T., Kim, Taeho, Wagner, John E., Conti, Brooke A., Lach, Francis P., Huang, Athena L., Molina, Henrik, Sanborn, Erica M., Zierhut, Heather, Cornes, Belinda K., Abhyankar, Avinash, Sougnez, Carrie, Gabriel, Stacey B., Auerbach, Arleen D., Kowalczykowski, Stephen C., Smogorzewska, Agata
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529964/
https://ncbi.nlm.nih.gov/pubmed/26253028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.009
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