Carregant...

Mechanism of DNA Interstrand Crosslink Processing by Repair Nuclease FAN1

DNA interstrand crosslinks (ICLs) are highly toxic lesions associated with cancer and degenerative diseases. ICLs can be repaired by the Fanconi Anemia (FA) pathway and through FA-independent processes involving the FAN1 nuclease. Here, FAN1-DNA crystal structures and biochemical data reveal that hu...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Science
Autors principals: Wang, Renjing, Persky, Nicole, Yoo, Barney, Ouerfelli, Ouathek, Smogorzewska, Agata, Elledge, Stephen J., Pavletich, Nikola P.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285437/
https://ncbi.nlm.nih.gov/pubmed/25430771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258973
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!