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Mechanism of DNA Interstrand Crosslink Processing by Repair Nuclease FAN1
DNA interstrand crosslinks (ICLs) are highly toxic lesions associated with cancer and degenerative diseases. ICLs can be repaired by the Fanconi Anemia (FA) pathway and through FA-independent processes involving the FAN1 nuclease. Here, FAN1-DNA crystal structures and biochemical data reveal that hu...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4285437/ https://ncbi.nlm.nih.gov/pubmed/25430771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258973 |
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