Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

Fanconi Anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand crosslinks (ICL). Central to this pathway is the FANCI-FANCD2 (ID) complex, which is activated by DNA damage-induced phosphorylation and monoubiquitination. The 3.4 Å crystal structure of the ~300 k...

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Bibliographic Details
Main Authors: Joo, Woo, Xu, Guozhou, Persky, Nicole S., Smogorzewska, Agata, Rudge, Derek, Buzovetsky, Olga, Elledge, Stephen J., Pavletich, Nikola P.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310437/
https://ncbi.nlm.nih.gov/pubmed/21764741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1205805
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